List
March 23rd, 2016

Rice germ oil as multifunctional excipient in preparation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus

Surmounting the constraints of limited solubilization efficiency and prime requisite of antioxidant for conventional lipid formulations, the research work explores […]
March 23rd, 2016

Drug loaded poly[Lac(Glc-Leu)] microparticles: Formulation and release characteristics

Valdecoxib has been entrapped in sub-5 μm particles of poly[Lac(Glc-Leu)] copolymer using a oil-in-water (o/w) emulsification-solvent evaporation technique. To achieve […]
March 23rd, 2016

Complexation approach for fixed dose tablet formulation of lopinavir and ritonavir: An anomalous relationship between stability constant, dissolution rate and saturation solubility

In the present investigation, cyclodextrin complexation process was explored for development of tablet formulation of WHO approved fixed dose combination […]
March 23rd, 2016

Pharmacokinetics of intramuscular microparticle depot of valdecoxib in an experimental model Pharmacokinetics of intramuscular microparticle depot

Aim: We did a prospective study to investigate pharmacokinetics of a single intramuscularly (i.m.) administered Valdecoxib (VC) polymeric microparticles in […]
March 23rd, 2016

Osmotic pellet system comprising osmotic core and in-process amorphized drug in polymer-surfactant layer for controlled delivery of poorly water-soluble drug

The aim of the present investigation was to develop controlled porosity osmotic system for poorly water-soluble drug based on drug […]
March 23rd, 2016

Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded nanosponges

The aim of this study was to evaluate the pharmacokinetics of paclitaxel-loaded nanosponges (PLN) in rats. The study also evaluates […]
March 23rd, 2016

Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity

Camptothecin (CAM), a plant alkaloid and a potent antitumor agent, has a limited therapeutic utility because of its poor aqueous […]
March 23rd, 2016

SMEDDS incorporated polymer matrix: A floating dosage form solution for drugs with poor gastric solubility

A new kind of gastro-retentlve dosage form for drugs with poor aqueous solubility was developed and evaluated, with the aim […]
March 23rd, 2016

In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of β-cyclodextrin

New swellable cyclodextrin-based poly(amidoamine) nanosponges, named PAA-NS10 and PAA-NS11, were synthesized by crosslinking β-cyclodextrin with either 2,2-bisacrylamidoacetic acid or with […]
March 23rd, 2016

Nanosponge formulations as oxygen delivery systems

Three types of cyclodextrin nanosponges were synthetized cross-linking α, β or γ cyclodextrin with carbonyldiimidazole as cross-linker. Nanosponges are solid […]