Two rapid, simple and accurate analytical methods have been developed for the quantitative estimation of Sumatriptan succinate (SMT) in pharmaceutical preparations. SMT forms blue colored chromogen with Folin Ciocaltaeu’s Phenol (F.C.) reagent which showed λ(max) at 760 nm and was found to be stable for 4 hours. The chromogen obeyed linearity over the concentration range of 2 to 16 mcg/ml. SMT was also chromatographed on a silica gel 60 F254 (E. Merck) plate using chloroform: methanol: ethyl acetate: ammonia (7.2:1:1.8:0.2 v/v/v) as mobile phase and samples were scanned at 247 nm. Drug obeyed linearity over the concentration range of 100ng to 1000ng. Both the methods were statistically evaluated for accuracy and precision. The recoveries, coefficient of correlation, coefficient of variation and standard deviation was calculated from experimental data. In order to justify the ruggedness of the method an elaborate study was made through interday and intraday analysis of marketed formulation.

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