List
March 23rd, 2016

Amorphous ternary cyclodextrin nanocomposites of telmisartan for oral drug delivery: Improved solubility and reduced pharmacokinetic variability

Despite of advancements in dosage form design and use of multifunctional excipients, improvement in dissolution characteristics of molecules like Telmisartan […]
March 23rd, 2016

Cyclodextrin-based nanosponges of curcumin: Formulation and physicochemical characterization

Curcumin is the source of the spice turmeric having potential application in tumor treatment but has limited therapeutic utility because […]
March 23rd, 2016

Nanosuspension based in situ gelling nasal spray of carvedilol: Development, in vitro and in vivo characterization

The objective of the present investigation was to develop in situ gelling nasal spray formulation of carvedilol (CRV) nanosuspension to […]
March 23rd, 2016

Soluble itraconazole in tablet form using disordered drug delivery approach: Critical scale-up considerations and bio-equivalence studies

The present research work explores formulation design, critical scale-up considerations and bio-equivalence studies of soluble itraconazole (ITZ) in a tablet […]
March 23rd, 2016

Encapsulation of Acyclovir in new carboxylated cyclodextrin-based nanosponges improves the agent’s antiviral efficacy

Cyclodextrin-based nanosponges (NS) are solid nanoparticles, obtained from the cross-linking of cyclodextrins that have been proposed as delivery systems for […]
March 23rd, 2016

Monolithic osmotic system of lornoxicam using amorphous ternary cyclodextrin complex as a core

The aim of the present investigation was to develop Monolithic Osmotic Tablet System (MOTS) of pH dependent and poorly water […]
March 23rd, 2016

Poly[LA-(Glc-Leu)] copolymer as a carrier for ocular delivery of ciprofloxacin: Formulation, characterization and in vivo biocompatibility study

Background: Ciprofloxacin hydrochloride-encapsulated poly[LA-(Glc-Leu)] copolymeric nanoparticles were prepared to provide sustained release and ameliorate shortcomings associated with eye drops. Methods: […]
March 23rd, 2016

Nanoemulsified orlistat-embedded multi-unit pellet system (MUPS) with improved dissolution and pancreatic lipase inhibition

The present research work explores an innovative technological solution to constraints in efficient oral delivery of poorly water-soluble anti-obesity drug […]
March 23rd, 2016

Self-assembled nanocomplexes of anionic pullulan and polyallylamine for DNA and pH-sensitive intracellular drug delivery

The amalgamation of chemotherapy and gene therapy is promising treatment option for cancer. In this study, novel biocompatible self-assembled nanocomplexes […]
March 23rd, 2016

Fabrication and statistical optimization of a polysaccharide-based sublingual film of buprenorphine hydrochloride for breakthrough pain management: In vitro and in vivo performance

A typical breakthrough pain episode is severe, categorized by a fast onset, typically reaches peak intensity instantly, and lasts for […]