List
March 23rd, 2016

Monolithic osmotic system of lornoxicam using amorphous ternary cyclodextrin complex as a core

The aim of the present investigation was to develop Monolithic Osmotic Tablet System (MOTS) of pH dependent and poorly water […]
March 23rd, 2016

Poly[LA-(Glc-Leu)] copolymer as a carrier for ocular delivery of ciprofloxacin: Formulation, characterization and in vivo biocompatibility study

Background: Ciprofloxacin hydrochloride-encapsulated poly[LA-(Glc-Leu)] copolymeric nanoparticles were prepared to provide sustained release and ameliorate shortcomings associated with eye drops. Methods: […]
March 23rd, 2016

Cyclodextrin-based nanosponges: effective nanocarrier for tamoxifen delivery.

The purpose of the present study was to develop Tamoxifen loaded β-cyclodextrin nanosponges for oral drug delivery. The three types […]
March 23rd, 2016

Design and evaluation of Lumefantrine – Oleic acid self nanoemulsifying ionic complex for enhanced dissolution

Background: Lumefantrine, an antimalarial molecule has very low and variable bioavailability owing to its extremely poor solubility in water. It […]
March 23rd, 2016

Structural evidence of differential forms of nanosponges of beta-cyclodextrin and its effect on solubilization of a model drug

Nanosponges (NS) are a recently developed class of hyper-branched polymers, nano-structured to form three dimensional meshwork; obtained by reacting cyclodextrins […]
March 23rd, 2016

Nanosponges encapsulating dexamethasone for ocular delivery: Formulation design, physicochemical characterization, safety and corneal permeability assessment

Nanosponges (NS) were synthesized by crosslinking of beta cyclodextrins with diphenyl carbonate. It is a hyper-branched polymer with an ultra […]
March 23rd, 2016

Physico-chemical characterization and in vivo pharmacodynamic evaluation of lyophilized meloxicam: β-cyclodextrin inclusion complexes

Objective: The objective of the present work was to enhance solubility, in vitro dissolution and in vivo pharmacodynamic activity of […]
March 23rd, 2016

Electron capture detection of oxybutynin in plasma: Precolumn derivatization approach and application to a pharmacokinetic study

Oxybutynin is an antimuscarinic agent used for the treatment of an overactive bladder. Because of its poor chromophore, it is […]
March 23rd, 2016

Serratiopeptidase Loaded Chitosan Nanoparticles by Polyelectrolyte Complexation: In Vitro and In Vivo Evaluation

The aim of the present study was to formulate serratiopeptidase (SER)-loaded chitosan (CS) nanoparticles for oral delivery. SER is a […]
March 23rd, 2016

Oral delivery of paclitaxel nanocrystal (PNC) with a dual Pgp-CYP3A4 inhibitor: Preparation, characterization and antitumor activity

Several molecular inheritances have severely restrained the peroral delivery of taxanes. The main objective of the present investigation was to […]