List
March 23rd, 2016

Oral delivery of paclitaxel nanocrystal (PNC) with a dual Pgp-CYP3A4 inhibitor: Preparation, characterization and antitumor activity

Several molecular inheritances have severely restrained the peroral delivery of taxanes. The main objective of the present investigation was to […]

March 23rd, 2016

Naltrexone-loaded poly[La-(Glc-Leu)] polymeric microspheres for the treatment of alcohol dependence: In vitro characterization and in vivo biocompatibility assessment

The poly[La-(Glc-Leu)] copolymer was applied in the present investigation as polymeric carrier to fabricate naltrexone (NTX)-loaded poly[La-(Glc-Leu)] microspheres in the […]

March 23rd, 2016

Arginoplexes: An arginine-anchored nanoliposomal carrier for gene delivery

There is a need of an efficient and safe nonviral gene delivery carrier due to promising future of nucleic acid-based […]

March 23rd, 2016

Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application

The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of […]

March 23rd, 2016

Nanoemulsified orlistat-embedded multi-unit pellet system (MUPS) with improved dissolution and pancreatic lipase inhibition

The present research work explores an innovative technological solution to constraints in efficient oral delivery of poorly water-soluble anti-obesity drug […]

March 23rd, 2016

Self-assembled nanocomplexes of anionic pullulan and polyallylamine for DNA and pH-sensitive intracellular drug delivery

The amalgamation of chemotherapy and gene therapy is promising treatment option for cancer. In this study, novel biocompatible self-assembled nanocomplexes […]

March 23rd, 2016

Fabrication and statistical optimization of a polysaccharide-based sublingual film of buprenorphine hydrochloride for breakthrough pain management: In vitro and in vivo performance

A typical breakthrough pain episode is severe, categorized by a fast onset, typically reaches peak intensity instantly, and lasts for […]

March 23rd, 2016

Bioavailability, bioequivalence, and in vitro-in vivo correlation of oxybutynin transdermal patch in rabbits

The first objective of the proposed research work includes comparative bioavailability and bioequivalence evaluation of oxybutynin transdermal patch with respect […]

March 23rd, 2016

Novel L-lactide-depsipeptide polymeric carrier for enhanced brain uptake of rivastigmine in treatment of alzheimer’s disease

The present study discusses possibility of targeting an anti-Alzheimer’s drug rivastigmine tartarate (RT) to the brain using novel synthesized L-lactide-depsipeptide […]

March 23rd, 2016

Electron capture detection of oxybutynin in plasma: Precolumn derivatization approach and application to a pharmacokinetic study

Oxybutynin is an antimuscarinic agent used for the treatment of an overactive bladder. Because of its poor chromophore, it is […]